MersV1, Main, Exploration, bibRecord, 000B62

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2

Identifieur interne : 000B62 ( Main/Exploration ); précédent : 000B61; suivant : 000B63

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2

Auteurs : Jyoti K. Jha [États-Unis] ; Mi Li [États-Unis] ; Rodolfo Ghirlando [États-Unis] ; Lisa M. Miller Jenkins [États-Unis] ; Alexander Wlodawer [États-Unis] ; Dhruba Chattoraj [États-Unis]

Source :

mBio [ 2150-7511 ] ; 2017.

RBID : PMC:5395669

Descripteurs français

KwdFr :
- ADN bactérien (métabolisme), Chaperons moléculaires (métabolisme), Chromosomes de bactérie (métabolisme), Helicase (métabolisme), Liaison aux protéines, Multimérisation de protéines, Origine de réplication, Protéines bactériennes (métabolisme), Réplication de l'ADN, Transactivateurs (métabolisme), Vibrio cholerae (croissance et développement), Vibrio cholerae (enzymologie), Vibrio cholerae (génétique).
MESH :
- croissance et développement : Vibrio cholerae.
- enzymologie : Vibrio cholerae.
- génétique : Vibrio cholerae.
- métabolisme : ADN bactérien, Chaperons moléculaires, Chromosomes de bactérie, Helicase, Protéines bactériennes, Transactivateurs.
- Liaison aux protéines, Multimérisation de protéines, Origine de réplication, Réplication de l'ADN.

English descriptors

KwdEn :
- Bacterial Proteins (metabolism), Chromosomes, Bacterial (metabolism), DNA Helicases (metabolism), DNA Replication, DNA, Bacterial (metabolism), Molecular Chaperones (metabolism), Protein Binding, Protein Multimerization, Replication Origin, Trans-Activators (metabolism), Vibrio cholerae (enzymology), Vibrio cholerae (genetics), Vibrio cholerae (growth & development).
MESH :
- chemical , metabolism : Bacterial Proteins, DNA Helicases, DNA, Bacterial, Molecular Chaperones, Trans-Activators.
- enzymology : Vibrio cholerae.
- genetics : Vibrio cholerae.
- growth & development : Vibrio cholerae.
- metabolism : Chromosomes, Bacterial.
- DNA Replication, Protein Binding, Protein Multimerization, Replication Origin.

Abstract

ABSTRACT

Replication of Vibrio cholerae chromosome 2 (Chr2) depends on molecular chaperone DnaK to facilitate binding of the initiator (RctB) to the replication origin. The binding occurs at two kinds of site, 12-mers and 39-mers, which promote and inhibit replication, respectively. Here we show that DnaK employs different mechanisms to enhance the two kinds of binding. We found that mutations in rctB that reduce DnaK binding also reduce 12-mer binding and initiation. The initiation defect is suppressed by second-site mutations that increase 12-mer binding only marginally. Instead, they reduce replication inhibitory mechanisms: RctB dimerization and 39-mer binding. One suppressing change was in a dimerization domain which is folded similarly to the initiator of an iteron plasmid—the presumed progenitor of Chr2. In plasmids, DnaK promotes initiation by reducing dimerization. A different mutation was in the 39-mer binding domain of RctB and inactivated it, indicating an alternative suppression mechanism. Paradoxically, although DnaK increases 39-mer binding, the increase was also achieved by inactivating the DnaK binding site of RctB. This result suggests that the site inhibits the 39-mer binding domain (via autoinhibition) when prevented from binding DnaK. Taken together, our results reveal an important feature of the transition from plasmid to chromosome: the Chr2 initiator retains the plasmid-like dimerization domain and its control by chaperones but uses the chaperones in an unprecedented way to control the inhibitory 39-mer binding.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395669

DOI: 10.1128/mBio.00427-17
PubMed: 28420739
PubMed Central: 5395669

Affiliations:

Le document en format XML

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 Chromosome 2</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacterial Proteins (metabolism)</term>
<term>Chromosomes, Bacterial (metabolism)</term>
<term>DNA Helicases (metabolism)</term>
<term>DNA Replication</term>
<term>DNA, Bacterial (metabolism)</term>
<term>Molecular Chaperones (metabolism)</term>
<term>Protein Binding</term>
<term>Protein Multimerization</term>
<term>Replication Origin</term>
<term>Trans-Activators (metabolism)</term>
<term>Vibrio cholerae (enzymology)</term>
<term>Vibrio cholerae (genetics)</term>
<term>Vibrio cholerae (growth & development)</term>
</keywords>
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<term>Chaperons moléculaires (métabolisme)</term>
<term>Chromosomes de bactérie (métabolisme)</term>
<term>Helicase (métabolisme)</term>
<term>Liaison aux protéines</term>
<term>Multimérisation de protéines</term>
<term>Origine de réplication</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Réplication de l'ADN</term>
<term>Transactivateurs (métabolisme)</term>
<term>Vibrio cholerae (croissance et développement)</term>
<term>Vibrio cholerae (enzymologie)</term>
<term>Vibrio cholerae (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Bacterial Proteins</term>
<term>DNA Helicases</term>
<term>DNA, Bacterial</term>
<term>Molecular Chaperones</term>
<term>Trans-Activators</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vibrio cholerae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chromosomes, Bacterial</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN bactérien</term>
<term>Chaperons moléculaires</term>
<term>Chromosomes de bactérie</term>
<term>Helicase</term>
<term>Protéines bactériennes</term>
<term>Transactivateurs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>DNA Replication</term>
<term>Protein Binding</term>
<term>Protein Multimerization</term>
<term>Replication Origin</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Liaison aux protéines</term>
<term>Multimérisation de protéines</term>
<term>Origine de réplication</term>
<term>Réplication de l'ADN</term>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Replication of <italic>Vibrio cholerae</italic>
 chromosome 2 (Chr2) depends on molecular chaperone DnaK to facilitate binding of the initiator (RctB) to the replication origin. The binding occurs at two kinds of site, 12-mers and 39-mers, which promote and inhibit replication, respectively. Here we show that DnaK employs different mechanisms to enhance the two kinds of binding. We found that mutations in <italic>rctB</italic>
 that reduce DnaK binding also reduce 12-mer binding and initiation. The initiation defect is suppressed by second-site mutations that increase 12-mer binding only marginally. Instead, they reduce replication inhibitory mechanisms: RctB dimerization and 39-mer binding. One suppressing change was in a dimerization domain which is folded similarly to the initiator of an iteron plasmid—the presumed progenitor of Chr2. In plasmids, DnaK promotes initiation by reducing dimerization. A different mutation was in the 39-mer binding domain of RctB and inactivated it, indicating an alternative suppression mechanism. Paradoxically, although DnaK increases 39-mer binding, the increase was also achieved by inactivating the DnaK binding site of RctB. This result suggests that the site inhibits the 39-mer binding domain (via autoinhibition) when prevented from binding DnaK. Taken together, our results reveal an important feature of the transition from plasmid to chromosome: the Chr2 initiator retains the plasmid-like dimerization domain and its control by chaperones but uses the chaperones in an unprecedented way to control the inhibitory 39-mer binding.</p>
</div>
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<name sortKey="Chattoraj, Dhruba" sort="Chattoraj, Dhruba" uniqKey="Chattoraj D" first="Dhruba" last="Chattoraj">Dhruba Chattoraj</name>
<name sortKey="Ghirlando, Rodolfo" sort="Ghirlando, Rodolfo" uniqKey="Ghirlando R" first="Rodolfo" last="Ghirlando">Rodolfo Ghirlando</name>
<name sortKey="Li, Mi" sort="Li, Mi" uniqKey="Li M" first="Mi" last="Li">Mi Li</name>
<name sortKey="Li, Mi" sort="Li, Mi" uniqKey="Li M" first="Mi" last="Li">Mi Li</name>
<name sortKey="Miller Jenkins, Lisa M" sort="Miller Jenkins, Lisa M" uniqKey="Miller Jenkins L" first="Lisa M." last="Miller Jenkins">Lisa M. Miller Jenkins</name>
<name sortKey="Wlodawer, Alexander" sort="Wlodawer, Alexander" uniqKey="Wlodawer A" first="Alexander" last="Wlodawer">Alexander Wlodawer</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B62 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B62 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5395669
   |texte=   The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28420739" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

Serveur d'exploration MERS

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.